NR3C1 and adrenal gland hyperfunction: First, CORT super-suppression following the DST reflects—and is interpreted as—hypersensitivity of GRs to GC-mediated negative feedback or higher GR expression levels, which is typically thought to occur in response to basal hypocortisolemia and has been reported in humans with PTSD [63,64,73], but not to the sustained hypercortisolemia found in MALT animals through 12 months.