ESR1 and Alzheimer disease: The 720 pharmacodynamic targets were imported into the STRING database for protein interaction analysis, removing the non-intersecting REG1A, and 578 targets with 2275 linkages remained, from which 86 key core protein targets with 519 linkages were screened out of the target network map, among which were SRC, STAT3, MAPK1, BRCA1, and JUN (core proteins closely related to inflammatory response), and HSP90AA1, ESR1, GRB2, Akt1, EGFR, and FYN (core proteins with positive effects on AD treatment and cell growth promotion), all of which have strong correlations with AD (Figure 2).