Notably, protein-truncating variants in BRCA1 (OR = 10.57, 95% CI: 8.02–13.93; p < 0.0001) and BRCA2 (OR = 5.85, 95% CI: 4.85–7.06; p < 0.0001) were strongly associated with increased BC risk [39]. This evidence concerns the gene BRCA1 and breast cancer.