SGCB and chronic kidney disease: Preclinical studies indicate that sGC stimulators and activators may have protective effects in different models of kidney injury, including CKD caused by unilateral ureteral obstruction in mice [10], Dahl salt-sensitive rats on high-salt diets [11], hypertensive renin-transgenic rats treated with NG-nitro-L-arginine methyl ester (L-NAME), and rats that have undergone 5/6 nephrectomy [12].