Among these mediators, pigment epithelium-derived factor (PEDF), Thrombospondin 1 (THBS1) and 2 (THBS2) are highly expressed in iCCA tissue, where they act as inhibitors of angiogenesis and promoters of lymphangiogenesis, thereby facilitating tumor cells dissemination. The gene discussed is SERPINF1; the disease is neoplasm.