In another trial, the authors investigated the effects of melatonin on breast cancer markers [insulin-like growth factor 1 (IGF-1), estradiol, insulin-like growth factor-binding protein-3 (IGFBP-3), and IGF-1/IGFBP-3 ratio] in postmenopausal breast cancer survivors. The gene discussed is IGFBP3; the disease is breast carcinoma.