Concurrently, exercise is recognized for its ability to stimulate the release of neurotrophic factors [proteins that support the growth, survival, and differentiation of neurons, as well as promote neurogenesis, synaptic plasticity, and repair of the nervous system, playing a critical role in maintaining neural health and function], like BDNF and insulin-like growth factor 1 (IGF-1), which enhance neural connectivity and reduce the risk of cognitive decline [7]. The gene discussed is BDNF; the disease is Mental deterioration.