These include mitogen-associated protein kinase [MAPK], Hippo, cyclic AMP [cAMP], Janus kinase/signal transducers and activators of transcription [JAK-STAT], and rat sarcoma [RAS] signaling pathways [18], nebulin (NEB), the metabolic regulator pyruvate kinase M1/2 (PKM1 and PKM2) [2], T-box transcription factors 5 and 20 (TBX5 and TBX20) [4], Forkhead box M1 (FOXM1) [8], GATA-binding protein 4 (GATA4) [20], bone morphogenetic protein (BMP), and Notch signaling pathways [21]. The gene discussed is GATA4; the disease is sarcoma.