ITPR1 and Reduced sperm motility: Heterozygous mutations in some genes can cause or increase the risk of male infertility such as GALNTL5 in asthenozoospermia [44]; CEP70, UBE2B and ITPR1 in azoospermia [45,46,47]; KLHL10 and PRKAR1A in oligozoospermia [48,49]; SEPT12 in oligoasthenozoospermia or asthenoteratozoospermia [50]; and ODF2 in multiple morphological abnormalities of the sperm flagella (MMAF) [51].