Given the neural excitotoxicity of polyamines downstream of ARG1 in specific contexts, such as in the rodent retina following intraocular injection of N-methyl-D-aspartate or during retinal ganglion cell exposure to polyamine degradation products [96,97,98], the question has to be raised if polyamines potentially also affect retinal neurons through mechanisms like excitotoxicity in the course of uveitis pathogenesis. This evidence concerns the gene ARG1 and uveitis.