In chronic neuropathic pain models, Fang et al. [64] found that after blocking TRPV4 with the antagonists RN-1734 and HC-067047, P2X7 expression in the dorsal root ganglion decreased, demonstrating that TRPV4-mediated P2X7 expression participates in the development of neuropathic pain. Here, TRPV4 is linked to Pain.