XRCC6 and colorectal carcinoma: Additionally, we found that HDGF is positively associated with DNA DSB repair and the HR pathway in CRC (Figure 3C), and that HDGF expression is positively correlated with the expressions of various HR-related genes, including XRCC5 (Ku80), XRCC6 (Ku70), RPA2, RAD51, RBBP8 (CtIP), BRCA1, BRCA2, and PALB2, among others (Figure 3B).