Primary resistance mechanisms include (a) resistance of the IFN-γ -signaling pathway [7,36,37]; (b) insufficient antigen presentation and/or antigen recognition [37,38,39,40,41]; (c) immunosuppressive tumor microenvironment [42,43,44,45,46,47,48,49]; (d) intrinsic oncogenic pathway [50]. The gene discussed is IFNG; the disease is neoplasm.