Silencing of ATG5, a key gene for autophagy, reduced cytokine secretion and airway hyperresponsiveness to varying degrees, suggesting that ATG5 is involved in the pathogenesis of asthma, whereas acupuncture at GV14, BL13, and ST36 in asthmatic mice inhibited ATG5-mediated autophagy, regulated ER stress, and CD4+ T-lymphocyte differentiation, and effectively attenuated asthmatic airway inflammation [85]. This evidence concerns the gene ATG5 and airway hyperresponsiveness.