The transcription factor EB (TFEB) is the most important regulator of the ALP pathway, and EA activates the TFEB-mediated ALP to promote lysosomal function, enhances autophagy, and synergistically supports degradation of the NLRP3 inflammatory vesicle component, effectively improving AD mice cognitive ability and neuroinflammation, and inhibiting the progression of Aβ pathology [112]. This evidence concerns the gene TFEB and Alzheimer disease.