Although there is no direct association between CFH and human MASLD in the literature, plasma CFH concentration is positively associated with BMI, waist circumference, triglycerides, and markers of systemic inflammation [49], and CFH knockout mice develop a phenotype similar to MASLD with hepatic steatosis, fibrosis, HCC, and elevated hepatic mRNA markers of inflammation [50]. Here, CFH is linked to metabolic dysfunction-associated steatotic liver disease.