The molecular mechanisms underlying the broadly neutralizing Abs induced by XBB/JN.1 infections were determined via high-throughput yeast-display-based DMS assays and the escape mutation profiles of a total of 2688 Abs, including 1874 isolated from XBB/JN.1 infection cohorts, were determined, producing a total of 22 Ab clusters [56]. Here, DDX41 is linked to infection.