In particular, in acute myeloid leukemia (AML), several drugs, like JA3 and JA7 [175], VAS3947 [176], CXL146 [177], Camalexin [178], RS-F3 [179], Quizartinib (AC220) [180], Cryptotanshinone [181], Oxalicumone A [182], Miltirone [183], Gossypol (BH3 mimetic) [184], curcumin [185,186], PYZD-4409 [187], Eicosapentaenoic acid [188], and Fenretinide [189], have been demonstrated to induce a cytotoxic response in the cell through terminal UPR induction mediated by PERK activation. Here, EIF2AK3 is linked to acute myeloid leukemia.