USP8 and Hepatic fibrosis: In liver fibrosis models and activated Kupffer cells (KCs), the elevated expression of METTL3 enhances metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) levels via m6A methylation and facilitates the degradation of ubiquitin-specific peptidase 8 (USP8) mRNA, subsequently reduces transforming growth factor β-activated kinase 1 (TAK1) regulation, enhances cell pyroptosis markers (NLRP3, caspase-1, GSDMD-N) and NF-κB p-p65 levels, thereby promoting macrophage pyroptosis and inflammation [58].