miR-146 has also been studied in bovine mastitis, and it has been shown to play a negative feedback role in the inflammatory process by down-regulating the Toll-Like Receptor 4/TNF Receptor-Associated Factor 6/NF-κB (TLR4/TRAF6/NF-κB) pathway [38]. The gene discussed is NFKB1; the disease is Bovine mastitis.