CROT and mitochondrial disease: Mitochondrial dysfunction, which is often characterized by impaired fatty acid oxidation and energy production, can be mitigated by modulating the activity of mitochondrial carnitine/acylcarnitine carrier, CRAT, CROT, and other acetyltransferases structurally related to CRAT, aiming to restore normal lipid transport and energy metabolism in cells affected by mitochondrial diseases.