5-Methoxyflavone is a flavonoid with DNA polymerase-β inhibitory properties that can inhibit the infiltration of inflammatory cells, alveolar edema, and cell apoptosis by decreasing the expression of inflammatory cytokines such as IL-6 and TNF-α in lung tissues, thus reducing the lung index and lung injury score of mice and alleviating LPS-induced ALI [45,49]. Here, TNF is linked to acute respiratory distress syndrome.