Tfh cells were found to regulate B-cell differentiation via CD40-CD40L; in renal tissue of nephritis, results indicate that Tfh cells (CD4+ICOS+) and B cells directly interact in situ in the glomerulus [30], with intensified signaling through LTA/TNFSF14 (LIGHT)-TNFRSF14 [27]. The gene discussed is TNFSF14; the disease is nephritis.