A study on colorectal cancer (CRC) conducted by Yao et al. revealed that methylation of H4R3 by PRMT1 recruits SMARCA4, an ATPase subunit of the SWI/SNF chromatin remodeling complex, which enhances EGFR signaling and subsequently induces the ability of CRC cells to proliferate, form colonies, and migrate [27]. This evidence concerns the gene DNAH8 and colorectal carcinoma.