UBC and amyotrophic lateral sclerosis: Among the top 20 enriched pathways, significant pathways included protein processing in the endoplasmic reticulum, mitosis, amyotrophic lateral sclerosis, metabolic pathways, ubiquitin-mediated protein degradation, autophagy, and the FoxO signaling pathway, most of which are closely related to organismal growth and metabolism (Figure 2D).