Subsequent KEGG and GO analyses demonstrate predominant enrichment of these potential hub genes within key diabetes-associated signal transduction pathways such as TNF signaling pathway, EGFR signaling pathway, MAPK signaling pathway, PI3K-AKT signaling pathway, IL-17 signaling pathway, and AGE-RAGE signaling pathways (Figure 4D,E). Here, RENBP is linked to diabetes mellitus.