Studies have indicated the role of SMOX signaling in neuroprotection through various pathways, including antioxidant signaling via Nrf2 in experimental stroke [101,102], neuroinflammation in cerebral ischemia via IL6/TNFa [39], and miR-340-5p/Smurf1 signaling in spinal cord injury [103]. This evidence concerns the gene IL6 and brain ischemia.