ALKBH5 drives 5’UTR m6A demethylation and fine-tunes SF3B1 translation, which directs the splicing of central DNA repair and epigenetic regulators during transformation (a process in which recipient bacteria directly ingest free DNA fragments from donor bacteria to acquire new genetic traits), affecting genomic stability and leukemia progression [29]. The gene discussed is ALKBH5; the disease is leukemia.