In the present study, we proved that ectopic expression of PHF8 in KRAS- or BRAF-mutant CRC cells upregulated the expression of PD-L1, KRAS, BRAF, and c-Myc by increasing the levels of transcriptional activation marks H3K4me3 and H3K27ac and decreasing the levels of transcriptional repression mark H3K9me2 within their promoters. Here, KRAS is linked to colorectal carcinoma.