TNF and neoplasm: We next explored the effect of the above treatments on anti-tumor immunity and found that, compared to monotherapy or control, daminozide combined with PD1 antibody significantly increased the infiltration of CD4 + and CD8 + T cells (Fig. 3E) and the levels of TNFα (Fig. 3F), Granzyme B (Fig. 3G) and IFN-γ (Fig. 3H) in tumor tissues.