Further analysis revealed a significant reduction in histone lysine demethylase PHF8 in the PD1 antibody-treated group (Fig. 1D), and there are studies demonstrating that PHF8 depletion induces a viral mimicry response in human colorectal adenocarcinoma by activating canonical immune signatures [29], supporting the selection of PHF8 for subsequent exploration. This evidence concerns the gene PHF8 and colorectal adenocarcinoma.