PHF8 and colorectal carcinoma: We also evaluated the effect of ectopic expression or knockdown of PHF8 on the migration and invasion of CRC cells and demonstrated that ectopic expression of PHF8 in LOVO and SW480 cells significantly promoted cell invasiveness (Fig. 6A), while knocking down PHF8 in HCT116 and RKO cells suppressed their invasiveness ability (Fig. 6B).