CD274 and colorectal carcinoma: In the present study, we proved that ectopic expression of PHF8 in KRAS- or BRAF-mutant CRC cells upregulated the expression of PD-L1, KRAS, BRAF, and c-Myc by increasing the levels of transcriptional activation marks H3K4me3 and H3K27ac and decreasing the levels of transcriptional repression mark H3K9me2 within their promoters.