Based on our observations we concluded that lung cancer cells and telomerase positive iPSC (CHiPSC22) express a novel TERT isoform called Delta 2–4 that retains the original open reading frame and potentially codes for a new protein and that HBECs that lack telomerase activity do not express Delta 2–4 isoform making the Delta 2–4 isoform restricted to cells that express appreciable levels of TERT. The gene discussed is TERT; the disease is lung cancer.