GSDMD and periodontitis: Therefore, we constructed the mice periodontitis model combined with periodontal injection of the pyroptosis inhibitor, YVAD.29 The western blot results showed that periodontal ligature increased the protein level of pro-IL-1β and enhanced the cleavages of CASPASE1 and GSDMD, while YVAD injection mitigated these effects (Fig. 5a).