BMAL1-downregulation aggravates atherosclerosis by affecting oxidative stress,32 and mice harboring Bmal1-deficient regulatory T cells exhibits increased visceral adipose tissue inflammation.35 Plus, our data revealed that the protein levels of BMAL1 and GSDMD display a reverse trend over time, we therefore speculated that the decreased BMAL1 is involved in the regulation of GSDMD-mediated pyroptosis, contributing to periodontitis progression. The gene discussed is GSDMD; the disease is atherosclerosis.