In addition, these cell clusters in the CSF showed comparatively increased expression of other genes/proteins associated with the encephalitogenic phenotype, including PD-1(PDCD1), CCL5, and CXCR619,22 and for genes/proteins expressed by cells proposed to be pathogenic in MS, such as CD161(KLRB1), CCR5, ITGA4, TNFRSF25, RORA, and MAF28,35. This evidence concerns the gene ITGA4 and myeloid sarcoma.