BHLHE40 and autoimmune disease: We noted that as compared with the other CCR6-expressing subgroups, the CCR6+(high)CCR2+ cells showed higher expression of genes linked to mouse models of autoimmune disease or a pathogenic profile in human Th17 cells, including RORC, IL23R, TBX21, IFNG, BHLHE40, CSF2 (encoding GM-CSF), IL1R1 and ABCB119,20.