However, the autophagy induced by RAB33A overexpression in cervical cancer cells was not inhibited by 3-methyladenine (3-MA), a PI3K inhibitor, (Supplementary Fig. S4a, b) and was independent of both Beclin1 (BECN1) and WD repeat domain, phosphoinositide interacting 2 (WIPI2) (Supplementary Fig. S4c, d). The gene discussed is RAB33A; the disease is cervical cancer.