S4e). Notably, the promotion of migration and invasion by RAB33A overexpression was reversed by knocking out ATG5 in cervical cancer cells (Fig. 4t). Using the lymph node metastasis model as mentioned above, we found that cervical cancer cells overexpressing RAB33A resulted in larger popliteal metastatic lymph nodes, while knocking out ATG5 or RhoC could reverse it (Fig. 4u, v). This evidence concerns the gene RHOC and cervical carcinoma.