PIK3CA and cancer: Thus, inhibition/silencing of PI3K, Akt, mTORC1, SREBP1, or SCD1 sensitizes (cancer) cells to ferroptosis27,30,36,107 and activating mutations in PIK3CA, which encodes for the catalytic subunit of PI3K, cause ferroptosis resistance in cancer cells via the SREBP1-SCD1-axis27,30.