In contrast, ACC1 (ACACA) and FAS (FASN) seem to be protective in cancer cells: their expression correlates with resistance to different small molecule ferroptosis inducers (including ML210, ML162, RSL3, and erastin) in primary adherent cancer cell lines, as expected from the function of fatty acid biosynthetic enzymes in decreasing the phospholipid PUFA proportion described here. This evidence concerns the gene FAS and cancer.