Accordingly, i) Akt activation by IGF1R suppresses ferroptosis by increasing creatine kinase B binding to GPX4100, ii) tyrosine kinase inhibition by lorlatinib interferes with SCD expression and sensitizes melanoma to ferroptosis101, and iii) initiation of cell death in murine macrophages by a α-tocopherol metabolite suppresses SREBP1 proteolytic maturation and SCD1 expression102. The gene discussed is AKT1; the disease is melanoma.