Growth differentiation factor 8 (GDF-8), also known as myostatin (MSTN), is highly expressed in skeletal muscle tissue and acts as negative regulator of muscle development.255 Functional analyses have shown a reduction in ferroptosis pathways in MSTN-edited sheep.256 In a mouse model of chronic obstructive pulmonary disease (COPD), muscle tissue exhibited an enriched ferroptosis pathway, accompanied by increased expression of MSTN. Here, MSTN is linked to chronic obstructive pulmonary disease.