For example, increased expression of the miRNAs miR-20a and miR-124 inhibits the expression of FPN, leading to the accumulation of intracellular iron.174–177 Overexpression of miR-200b suppresses ferritin expression, consequently reducing iron storage.178 In addition, upregulation of myocardial miR-15a-5p, which targets GPX4 mRNA, has been observed in a mouse model of acute myocardial infarction.179 This overexpression enhances ferroptosis, in turn exacerbating hypoxic damage in cardiomyocytes. Here, GPX4 is linked to myocardial infarction.