MB and nutritional disorder: Mice with iron overload showed delayed muscle regeneration, reduced size of regenerated muscle fibers, decreased expression of myoblast differentiation markers, and decreased phosphorylation of mitogen-activated protein kinase (MAPK) signaling pathway after CTX-induced muscle injury.101 In addition, iron deficiency also reduces myoglobin expression and mitochondrial oxygen-consuming capacity, thereby reducing myoblast proliferation.79 Therefore, the imbalance of iron metabolism may destroy the ability of satellite cell proliferation, which may damage their ability to regenerate muscle tissue.