NLRP3 and diabetic cardiomyopathy: Inhibiting NLRP3 and pyroptosis reversed high-sugar/high-fat‒induced cardiomyocyte dysfunction, similar to the effects of liproxstatin-1 and the mitochondrial antioxidant MitoQ.229 This suggests that ferroptosis in cardiomyocytes in diabetic cardiomyopathy is regulated by NLRP3-dependent pyroptosis.