ACSL4 and amyotrophic lateral sclerosis: Bioinformatics analyses of the Gene Expression Omnibus (GEO) datasets GSE153960 and GSE112680 have highlighted significant differences in the expression of ferroptosis-related genes—such as cytochrome b beta (CYBB), lysosome-associated membrane glycoprotein 2 (LAMP2), ACSL4, and SLC38A1—between ALS patients and control groups.300 Moreover, gene set enrichment analysis (GSEA) revealed that the ferroptosis pathway is more activated in ALS patients, as indicated by higher enrichment score.