GPX4 and cardiomyopathy: A natural dietary cannabinoid, β-Caryophyllene (BCP), can terminate free radical chain reactions by interacting with molecular oxygen, protecting cardiomyocytes from cellular ferroptosis caused by cysteine deficiency or GPX4 inactivation.466 In addition, BCP can maintain mitochondrial morphological integrity and restore mitochondrial function, and oral administration of BCP (50 mg/kg daily) significantly alleviates DOX-induced myocardial atrophy and cardiomyopathy in mice.