Following myocardial ischemia/reperfusion (I/R) injury, ALOX15 metabolites accumulate in ferroptotic cardiomyocytes, and ferroptosis is significantly reduced in cardiomyocyte-specific Alox15 knockout mice.118 Furthermore, 15-hydroperoxyeicosatetraenoic acid (15-HpETE), an intermediate metabolite of ALOX15, has been identified as a trigger for ferroptosis in cardiomyocytes. Here, ALOX15 is linked to myocardial ischemia.