Similarly, knocking down ELAVL1 reduced ferroptosis, ameliorated I/R injury, and shrunk myocardial infarct area.441 Mechanistically, the study revealed that the transcription factor FOXC1 (forkhead box C1) binds to the ELAVL1 promoter region during I/R, activating its transcription. Here, ELAVL1 is linked to myocardial infarction.