Recently, Tang et al. showed that the upregulation of p53 and TfR1 in rats following I/R injury was accompanied by increased ferroptosis and upregulated ubiquitin-specific protease 7 (USP7).439 Mechanistically, the authors showed that USP7 promotes myocardial ferroptosis in their I/R model by activating the p53/TfR1 pathway, while inhibiting USP7 protected against myocardial I/R injury by reducing ferroptosis.439 This novel USP7/p53/TfR1 pathway may therefore represent a new target for treating myocardial ischemia. This evidence concerns the gene USP7 and myocardial ischemia.