GPX4 and cardiomyopathy: Inhibition of the ISR in these mice affects cardiac GSH metabolism, reduces GPX4 level, and promotes lipid peroxidation in the heart, ultimately leading to ferroptosis.317 These results suggest that the OMA1-Dele1-ATF4‒mediated ISR signal transduction pathway may protect against ferroptosis and may delay the progression of cardiomyopathy induced by the absence of cardiac Cox10.