Inhibition of CHMP5, however, was shown to increase ferroptosis.299 Previous studies have also found that elevated levels of CHMP5 in the blood correlate with reduced life expectancy in ALS patients, suggesting that CHMP5 could serve as a possible prognostic biomarker for ALS.300 These findings underscore a correlation between FIRGs and ALS, offering new avenues for research into the mechanisms underlying the loss of motor neurons in this disease. The gene discussed is CHMP5; the disease is amyotrophic lateral sclerosis.