METTL3 and Aortic dissection: More importantly, overexpression of METTL3 in HASMCs promoted erastin- and cystine deprivation-induced ferroptosis, while knocking down METTL3 increased both SLC7A11 and FSP1 expression and reduced ferroptosis,358 suggesting that ferroptosis plays a crucial pathogenic role in aortic dissection.