Bioinformatics analyses of the Gene Expression Omnibus (GEO) datasets GSE153960 and GSE112680 have highlighted significant differences in the expression of ferroptosis-related genes—such as cytochrome b beta (CYBB), lysosome-associated membrane glycoprotein 2 (LAMP2), ACSL4, and SLC38A1—between ALS patients and control groups.300 Moreover, gene set enrichment analysis (GSEA) revealed that the ferroptosis pathway is more activated in ALS patients, as indicated by higher enrichment score. Here, CYBB is linked to amyotrophic lateral sclerosis.