Fibroblast Growth Factor 21 (FGF21) is a peptide hormone synthesized by several organs such as skeletal muscle and myocardium with pleiotropic effects on glucose and lipid homeostasis to maintain energy balance.259,260 Iron overload promotes ferroptosis in liver cells by inducing HO-1 expression, leading to liver fibrosis. This evidence concerns the gene FGF21 and Hepatic fibrosis.