CHMP5 and amyotrophic lateral sclerosis: For example, single-nucleus RNA sequencing and bulk RNA sequencing data have identified ferroptosis and iron metabolism-related genes (FIRGs), including ACSL4 and CHMP5 (which encodes the chromatin-modifying protein-charged multivesicular body protein 5), are involved in the pathogenesis of ALS primarily by affecting calcium signaling pathways, synaptic pathways, and a variety of immune pathways.298 CHMP5 has also been shown to accumulate in the plasma membrane during ferroptosis, reducing lipid peroxidation and participating in the regulation of ferroptosis.