BACH1 and myocardial infarction: This repression increases the susceptibility of cardiac muscle cells to ferroptosis.172,173 Importantly, Bach1 knockout mice demonstrate greater resistance to myocardial infarction compared to wild-type counterparts.173 BACH1 promotes ferroptosis by disrupting the balance between the induction of protective genes and the accumulation of iron-mediated damage at the transcriptional level.