AKT1 and myocardial ischemia: Similarly, BMSC-CM protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced injury by modulating notch2/mTOR/autophagy signaling pathway [65], while BMSC-derived exosomal miRNA-29c attenuates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy via PTEN/Akt/mTOR signaling pathway [66].