Interestingly, the most common alterations associated to late-life depression, such as neurotransmitter imbalance, hypothalamus–pituitary–adrenal (HPA) axis dysregulation, reduction of nerve growth factors, vascular disease and neuroinflammation are linked to pathological changes in the ageing brain, including Alzheimer’s disease (AD)-related pathology (amyloid accumulation, tau aggregation, neurodegeneration), and cerebrovascular pathologies, which often co-exist (Rahimi and Kovacs 2014; Alexopoulos 2019). This evidence concerns the gene MAPT and Alzheimer disease.