CEACAM5 and adenocarcinoma: The multivariate Cox proportional hazards regression analysis (Fig. 3) identified 4 independent risk factors associated with EFS (P < 0.05 and HR > 1.1 or HR < 0.9): WST (surgical treatment vs non-surgical treatment: HR = 0.52, P = 0.003); HT (moderately to well-differentiated adenocarcinoma vs poorly differentiated adenocarcinoma: HR = 0.41, P < 0.001); CEA at LFU (HR = 1.15, P = 0.031); and Preop-AGR (HR = 0.05, P = 0.023).