PACS1 and Neurodevelopmental delay: Moreover, the missense mutation PACS1R203W, identified in the majority of PACS1-NDD patients [25–27], potentiates PACS1/HDAC6 interaction leading to increased deacetylation of α-tubulin affects microtubule organization and Golgi structure in patient-derived cells and PACS1 syndrome mice [18].