ATF7IP acts as a transcription factor, facilitating the expression of TERT, also implicated as being involved in TGCT susceptibility through GWASs, and its corresponding RNA component, TERC. 39ATF7IP also interacts with SP1,39 which was also identified in this study, linking the pathway of chromatin organization to TGCT susceptibility. The gene discussed is SP1; the disease is testicular germ cell tumor.