CXCL12 and psoriasis: These results are consistent with previous observations that CXCL12 and ANGPTL4 regulate psoriasis via modulating hyperproliferation and inflammation of keratinocytes in psoriasis skin.[35, 36] Taken together, through the multiscale analysis of spatial heterogeneity in skin tissue, SMILE is able to uncover the differential cellular compositions and microenvironments between healthy and psoriatic conditions.