TREX1 and Aicardi-Goutieres syndrome: To evaluate the fractional resynthesis rates of STING in a disease relevant model of inflammation, we generated a transgenic mouse model of AGS by mutation of the mouse Trex1 gene resulting in the D18N point mutation into C57BL6 mice to generate C57BL/6NCrl-Trex1tm1.1(D18N)Geno/Gsk, herein Trex1D18N (S1 Fig).