Moreover, there are different HLA class II genes among Jordanians MS patients that are linked with several MS manifestations, such as: the HLA-DRB1 * 15:01 and HLA-DQB1 * 06:01 alleles increase the likelihood of optic neuritis, HLA-DRB1 * 07:01 is linked to brainstem symptoms, and sensory impairment was linked with HLA-DQB1 * 05:01 and HLA-DQB1 * 06:02 alleles. Here, HLA-DRB1 is linked to optic neuritis.