In a recent study, HLA-DR * 15 allele subtypes have been shown to work as an autoreactive T cell repertoire, in which the HLA-DRB1 * 15 allele’s immunopeptidome presenting the foreign peptides and self-antigens are same as to autoreactive CD4 + T cells in MS [16]. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.