While the HLA-DRB1 * 03:01, HLA-DRB1 * 11:01, and HLA-DRB1 * 15:01 alleles were the most frequently observed in MS patients with sensory impairment, but they do not reach a statistically significant association (S3 Table). This evidence concerns the gene HLA-DRB1 and Somatic sensory dysfunction.