In M vs. C, the top 15 significantly enriched pathways were prion disease, diabetic cardiomyopathy, Parkinson disease, Rap1 signaling pathway, circadian rhythm, Ras signaling pathway, chemical carcinogenesis-reactive oxygen species, EGFR tyrosine kinase inhibitor resistance, Huntington disease, thyroid hormone signaling pathway, focal adhesion, non-alcoholic fatty liver disease, Alzheimer disease, thermogenesis, apoptosis (Fig 3A and S8 Table). The gene discussed is TG; the disease is prion disease.