Six of the 32 genes (MPC2, NDUFC2, COX6A1, TMCO1, COPZ1, and COX8A), as well as TM4SF4, showed significantly higher expression values in HCC compared with non-HCC liver cases (all p < 0.001; S4 Table). The gene discussed is COX8A; the disease is hepatocellular carcinoma.