IL6 and cancer: The activation of “NF kappa B signaling pathway” [50], “PI3K Akt signaling pathway” [51,52], “Bcell receptor signaling pathway” [53] and “cancer pathway” are closely related to inflammation and oxidative stress, in which NF kappa B is a key transcription factor that initiates inflammation and regulates a variety of cytokines, including TNF-a, IL-1b, IL-6 and IL-18.