Moreover, through the study of the transcriptional profiles of CD4+ and CD8+ T cells in ECs, it has been shown that the phenotype of HIV infection control is associated with differential expression of proteins such as KZNF, which is implicated in the repression of regulatory elements derived from transposable elements for genes related to antiviral activity, leading to increased resistance to HIV infection [132]. Here, CD4 is linked to HIV infectious disease.