USP47 and cancer: To validate the results, we evaluated the mRNA levels of USP47 in 91 paired GC tissue samples from an in-house dataset and our ongoing in-house early-onset (FUEOGC) and late-onset (FULOGC) GC cohorts, which demonstrated marked higher USP47 expression in cancer specimens relative to the adjacent normal tissues (Figure 1D and Supplemental Figure 3, C and D).