In S180 tumor-bearing mice, β-d-Glucan significantly enhanced the mouse immune responses by, among other effects, decreasing the ratio of CD4 to CD8 lymphocytes [58] In our study, in NB patients, S. cerevisiae showed a negative correlation with monocytes expressing PD-2L and a positive correlation with CD4-/CD8-lymphocytes expressing CD3. Here, CD4 is linked to neoplasm.