In the GDS, even in metabolically adequately controlled people with recent-onset T1D (average HbA1c 6.7%), whole-body insulin-stimulated glucose disposal was inversely associated with the degree of fasting glycemia (107), with the sum of plasma levels of hexoses as the strongest predictor for insulin resistance supporting the harmful role of hyperglycemia (108). This evidence concerns the gene INS and type 1 diabetes mellitus.