The molecular mechanisms involve a primary effect of hyperglycemia to enhance mitochondrial production of reactive oxygen species (ROS) (126) which subsequently activates the hexosamine (127) and polyol pathways (128), protein kinase-C isoforms (PKC-β and PKC-δ) (129), and the formation of advanced glycation end-products (130) in capillary endothelial cells. Here, PRKCD is linked to Hyperglycemia.