INS and hyperinsulinism: In nonobese inadequately controlled (average HbA1c 7.7-8.6%) insulin-resistant individuals with long-standing T1D, intramyocellular triglyceride content measured by 1H-MRS (38) or biopsies (173) was increased by over 2-fold vs healthy controls, was inversely associated with insulin-stimulated glucose disposal during euglycemic–hyperinsulinemia and was independent of overall adiposity; these defects were similar to those observed in overweight individuals with T2D and their glucose-tolerant normal-weight first-degree relatives.