INS and hyperinsulinism: As to insulin-mediated regulation of EGP, some studies reported only partial EGP suppression during both physiological (24, 38, 39, 49, 51) and supraphysiological hyperinsulinemia (52) suggesting hepatic insulin resistance, whereas other studies found no differences compared with glucose-tolerant people, despite comparable insulinemia (12, 14, 15, 18, 21, 22, 55, Table 1).