Children and adolescents with newly diagnosed T1D (average HbA1c 11.2%, BMI 16.5 kg/m2) and adults with long-standing T1D (average HbA1c 7.5%, BMI 24.1 kg/m2) showed increments in glucagon responses to hyperglycemia after a liquid mixed meal (158) or a 50-g oral glucose load (159) irrespective of ambient glycemia. Here, GCG is linked to Hyperglycemia.