During euglycemic-hyperinsulinemia, glucose oxidation was shown to increase 7-fold in glucose-tolerant humans but only 4-fold in insulin-resistant individuals with T1D; basal lipid oxidation was 3-fold higher in the T1D participants and, in contrast to controls, it was marginally suppressed by insulin suggesting metabolic inflexibility (206). The gene discussed is INS; the disease is type 1 diabetes mellitus.