In 18.168 people with T1D from the Swedish National Diabetes Register followed for 6.8 years, a study investigated the association between CSII treatment and cardiovascular mortality and showed that CSII reduced fatal coronary heart disease, fatal CVD, and all-cause mortality by 45%, 42%, and 27%, respectively vs intensified insulin treatment with MDIs (350). The gene discussed is INS; the disease is coronary artery disorder.