To unbiasedly understand the induction of tumor VEGFA expression via GPR65 signaling, we first constructed a CAR T-cell treatment–specific tumor cell interactome from scRNA-seq data of m.CR tumors using SJARACNe (50) and then performed differential activity (DA) and DE analysis using NetBID2 (Supplementary Fig. S10A; ref. 25). This evidence concerns the gene VEGFA and neoplasm.